Prof. Dr. Andrew E. Greene

Título da Conferência: RECENT NATURAL PRODUCT SYNTHESIS WITH KETENES

Andrew E. Greene
LEDSS 3, Chimie Recherche, Université Joseph Fourier
BP 53X, 38041 Grenoble Cedex, France
(E-mail: Andrew.Greene@ujf-grenoble-fr


Synthetically appealing transformations based on chlorinated ketenes continue to be uncovered in spite of the nearly 35 years that have elapsed since their initial preparation.  We have been most interested in recent years in developing a diastereofacially selective 2+2 cycloaddition reaction of these ketenes with chiral olefins to generate chlorinated cyclobutanones in high diastereomeric excess, and in exploiting the rich chemistry of these cycloadducts.



In this lecture, the effectiveness of this mehtodology for the synthesis of a variety of enantiopure natural products will be demonstrated by the recent preparation of natural cyclopentanones, g-butyrolactones, and g-butyrolactams derivatives.


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