This course will cover some new topics on the chemistry and biochemistry of metal-based drugs and imaging agents. The topics include:

1 Ligand inhibition of metalloenzime function. The design and discovery of new classes of clinically useful agents capable of inhibiting specific metalloenzymes such as metalloproteases will be discussed.

2 Modification of cellular responses by inorganic agents. The role of nitric oxide and its biochemistry will be discussed.

3 Vanadium compounds as possible insulin modifiers. The evidence for the suggestion that some vanadium salts may be useful in diabetes treatment will be reviewed.

4 Platinum antitumor agents. Is the trans-geometry antitumor active? Recent literature challenging the established structure-activity relationships will be reviewed.

5 Imaging agents. Tecnetium compounds are used extensively to image body tissue. The principles behind the use of radioactive agents will be examined.

6 Paramagnetic metal complexes as contrast agents for magnetic resonance imaging (MRI). The success of MRI is based on the use of paramagnetic metal agents for contrast enhancement. Their structures and the physical principles behind their use will be discussed.

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